A key goal is to utilise this huge genetic and health information resource and the discoveries made from its research work to develop personalised medicine. The purpose of the FinnGen study is to understand the connections between genes and diseases and biological disease mechanisms. Contact FinnGen's support and start researching the Finnish genome today!

Contact

Research

Researchers from the University of Turku and the wellbeing services county of Southwest Finland are actively collaborating internationally on FinnGen research data. The genetic and health data of five hundred thousand people has been used to find new connections between genetic variants and different diseases. The goal for the next few years is to increase understanding of the development of health and various diseases as a person ages and to find biological bases for previously identified genetic signals. The medical breakthroughs resulting from the research project will ultimately benefit healthcare systems and patients worldwide.

Researchers

Matti Vuori Specialist in Internal Medicine, Doctor of Medicine
Postdoctoral researcher and clinical coordinator, FIMM, Department of Heart Failure
Tyks, Specialist

I study the genetic background of heart failure subtypes, especially heart failure with preserved ejection fraction (HFpEF).

Publications by researchers from the University of Turku and the wellbeing services county of Southwest Finland

Hasser EK, Brody JA, Bartz TM, Thibord F, Li-Gao R, Kauko A, Wiggins KL, Teder-Laving M, Kim J, Munsch G, Haile HG, Deleuze JF, van Hylckama Vlieg A, Wolberg AS, Boland A, Morange PE; FinnGen, Estonia Biobank research team; Kraft P, Lowenstein CJ, Emmerich J, Sitlani CM, Suchon P, Rosendaal FR, Niiranen T, Kabrhel C, Trégouët DA, Smith NL.
J Thromb Haemost. 2024 May 21:S1538-7836(24)00294-0. doi: 10.1016/j.jtha.2024.05.011.
Martiskainen H, Willman R-M, Heikkinen S, Müller SA, Sinisalo R, Takalo M, Mäkinen P, Kuulasmaa T, Pekkala V, Galván del Rey A, Harju P, Juopperi S-P, Jeskanen H, Kervinen I, Saastamoinen K, FinnGen, Niiranen M, Heikkinen SV, Kurki MI, Marttila J, Mäkinen PI, Ngandu T, Lehtisalo J, Bellenguez C, Lambert J-C, Haass C, Rinne J, Hakumäki J, Rauramaa T, Krüger J, Soininen H, Haapasalo A, Lichtenthaler SF, Leinonen V, Solje E, Hiltunen M.
medRxiv 2024.05.09.24307099; doi: https://doi.org/10.1101/2024.05.09.24307099
Ryu J, Rämö JT, Jurgens SJ, Niiranen T, Sanna-Cherchi S, Bauer KA, Haj A, Choi SH, Palotie A, Daly M, Ellinor PT, Bendapudi PK.
Blood. 2024 Mar 18:blood.2023023326. doi: 10.1182/blood.2023023326.
Nurkkala JM, Aittokallio J; FinnGen; Kauko A, Niiranen T.
Interdiscip Cardiovasc Thorac Surg. 2024 Jan 12:ivae006. doi: 10.1093/icvts/ivae006.
Nurmi AK, Pelttari LM, Kiiski JI, Khan S, Nurmikolu M, Suvanto M, Aho N, Tasmuth T, Kalso E, Schleutker J, Kallioniemi A, Heikkilä P; FinnGen; Aittomäki K, Blomqvist C, Nevanlinna H
Sci Rep. 2023 Nov 30;13(1):21127. doi: 10.1038/s41598-023-47441-w
Kauko A, Engler D, Niiranen T, Ortega-Alonso A, Schnabel RB
J Intern Med. 2023 Oct 29. doi: 10.1111/joim.13733
Vuori MA, Kiiskinen T, Pitkänen N, Kurki S, Laivuori H, Laitinen T, Mäntylahti S, Palotie A, FinnGen, Niiranen TJ.
BMC Res Notes. 2023 Sep 11;16(1):208. doi: 10.1186/s13104-023-06469-x.
Miller EC, Kauko A, Tom SE, Laivuori H, Niiranen T, Bello NA; FinnGen Investigators.
Stroke. 2023 May 22. doi: 10.1161/STROKEAHA.123.043052.
Ebinger JE, Kauko A; FinnGen; Bello NA, Cheng S, Niiranen T.
Eur J Prev Cardiol. 2023 Mar 2:zwad066. doi: 10.1093/eurjpc/zwad066.
Nurkkala J, Kauko A, FinnGen, Laivuori H, Saarela T, Tyrmi JS, Vaura F, Cheng S, Bello NA, Aittokallio J, Niiranen T.
J Hypertens. 2023 Mar 1;41(3):380-387. doi: 10.1097/HJH.0000000000003336.
Kiiskinen T, Helkkula P, Krebs K, Karjalainen J, Saarentaus E, Mars N, Lehisto A, Zhou W, Cordioli M, Jukarainen S, Rämö JT, Mehtonen J, Veerapen K, Räsänen M, Ruotsalainen S, Maasha M; FinnGen; Niiranen T, Tuomi T, Salomaa V, Kurki M, Pirinen M, Palotie A, Daly M, Ganna A, Havulinna AS, Milani L, Ripatti S.
Nat Med. 2023 Jan;29(1):209-218. doi: 10.1038/s41591-022-02122-5
Kurki MI, Karjalainen J, Palta P, Sipilä TP, Kristiansson K, Donner KM, Reeve MP, Laivuori H, Aavikko M, Kaunisto MA, Loukola A, Lahtela E, Mattsson H, Laiho P, Della Briotta Parolo P, Lehisto AA, Kanai M, Mars N, Rämö J, Kiiskinen T, Heyne HO, Veerapen K, Rüeger S, Lemmelä S, Zhou W, Ruotsalainen S, Pärn K, Hiekkalinna T, Koskelainen S, Paajanen T, Llorens V, Gracia-Tabuenca J, Siirtola H, Reis K, Elnahas AG, Sun B, Foley CN, Aalto-Setälä K, Alasoo K, Arvas M, Auro K, Biswas S, Bizaki-Vallaskangas A, Carpen O, Chen CY, Dada OA, Ding Z, Ehm MG, Eklund K, Färkkilä M, Finucane H, Ganna A, Ghazal A, Graham RR, Green EM, Hakanen A, Hautalahti M, Hedman ÅK, Hiltunen M, Hinttala R, Hovatta I, Hu X, Huertas-Vazquez A, Huilaja L, Hunkapiller J, Jacob H, Jensen JN, Joensuu H, John S, Julkunen V, Jung M, Junttila J, Kaarniranta K, Kähönen M, Kajanne R, Kallio L, Kälviäinen R, Kaprio J; FinnGen; Kerimov N, Kettunen J, Kilpeläinen E, Kilpi T, Klinger K, Kosma VM, Kuopio T, Kurra V, Laisk T, Laukkanen J, Lawless N, Liu A, Longerich S, Mägi R, Mäkelä J, Mäkitie A, Malarstig A, Mannermaa A, Maranville J, Matakidou A, Meretoja T, Mozaffari SV, Niemi MEK, Niemi M, Niiranen T, O Donnell CJ, Obeidat ME, Okafo G, Ollila HM, Palomäki A, Palotie T, Partanen J, Paul DS, Pelkonen M, Pendergrass RK, Petrovski S, Pitkäranta A, Platt A, Pulford D, Punkka E, Pussinen P, Raghavan N, Rahimov F, Rajpal D, Renaud NA, Riley-Gillis B, Rodosthenous R, Saarentaus E, Salminen A, Salminen E, Salomaa V, Schleutker J, Serpi R, Shen HY, Siegel R, Silander K, Siltanen S, Soini S, Soininen H, Sul JH, Tachmazidou I, Tasanen K, Tienari P, Toppila-Salmi S, Tukiainen T, Tuomi T, Turunen JA, Ulirsch JC, Vaura F, Virolainen P, Waring J, Waterworth D, Yang R, Nelis M, Reigo A, Metspalu A, Milani L, Esko T, Fox C, Havulinna AS, Perola M, Ripatti S, Jalanko A, Laitinen T, Mäkelä TP, Plenge R, McCarthy M, Runz H, Daly MJ, Palotie A.
Nature. 2023 Jan;613(7944):508-518. doi: 10.1038/s41586-022-05473-8
Nurkkala J, Kauko A, Palmu J, Aittokallio J, Niiranen T.
Front Cardiovasc Med. 2022 Nov 29;9:1021363. doi: 10.3389/fcvm.2022.1021363.
Mishra A, Malik R, Hachiya T, Jürgenson T, Namba S, Posner DC, Kamanu FK, Koido M, Le Grand Q, Shi M, He Y, Georgakis MK, Caro I, Krebs K, Liaw YC, Vaura FC, Lin K, Winsvold BS, Srinivasasainagendra V, Parodi L, Bae HJ, Chauhan G, Chong MR, Tomppo L, Akinyemi R, Roshchupkin GV, Habib N, Jee YH, Thomassen JQ, Abedi V, Cárcel-Márquez J, Nygaard M, Leonard HL, Yang C, Yonova-Doing E, Knol MJ, Lewis AJ, Judy RL, Ago T, Amouyel P, Armstrong ND, Bakker MK, Bartz TM, Bennett DA, Bis JC, Bordes C, Børte S, Cain A, Ridker PM, Cho K, Chen Z, Cruchaga C, Cole JW, de Jager PL, de Cid R, Endres M, Ferreira LE, Geerlings MI, Gasca NC, Gudnason V, Hata J, He J, Heath AK, Ho YL, Havulinna AS, Hopewell JC, Hyacinth HI, Inouye M, Jacob MA, Jeon CE, Jern C, Kamouchi M, Keene KL, Kitazono T, Kittner SJ, Konuma T, Kumar A, Lacaze P, Launer LJ, Lee KJ, Lepik K, Li J, Li L, Manichaikul A, Markus HS, Marston NA, Meitinger T, Mitchell BD, Montellano FA, Morisaki T, Mosley TH, Nalls MA, Nordestgaard BG, O’Donnell MJ, Okada Y, Onland-Moret NC, Ovbiagele B, Peters A, Psaty BM, Rich SS, Rosand J, Sabatine MS, Sacco RL, Saleheen D, Sandset EC, Salomaa V, Sargurupremraj M, Sasaki M, Satizabal CL, Schmidt CO, Shimizu A, Smith NL, Sloane KL, Sutoh Y, Sun YV, Tanno K, Tiedt S, Tatlisumak T, Torres-Aguila NP, Tiwari HK, Trégouët DA, Trompet S, Tuladhar AM, Tybjærg-Hansen A, van Vugt M, Vibo R, Verma SS, Wiggins KL, Wennberg P, Woo D, Wilson PWF, Xu H, Yang Q, Yoon K; COMPASS Consortium; INVENT Consortium; Dutch Parelsnoer Initiative (PSI) Cerebrovascular Disease Study Group; Estonian Biobank; PRECISE4Q Consortium; FinnGen Consortium; NINDS Stroke Genetics Network (SiGN); MEGASTROKE Consortium; SIREN Consortium; China Kadoorie Biobank Collaborative Group; VA Million Veteran Program; International Stroke Genetics Consortium (ISGC); Biobank Japan; CHARGE Consortium; GIGASTROKE Consortium, Millwood IY, Gieger C, Ninomiya T, Grabe HJ, Jukema JW, Rissanen IL, Strbian D, Kim YJ, Chen PH, Mayerhofer E, Howson JMM, Irvin MR, Adams H, Wassertheil-Smoller S, Christensen K, Ikram MA, Rundek T, Worrall BB, Lathrop GM, Riaz M, Simonsick EM, Kõrv J, França PHC, Zand R, Prasad K, Frikke-Schmidt R, de Leeuw FE, Liman T, Haeusler KG, Ruigrok YM, Heuschmann PU, Longstreth WT, Jung KJ, Bastarache L, Paré G, Damrauer SM, Chasman DI, Rotter JI, Anderson CD, Zwart JA, Niiranen TJ, Fornage M, Liaw YP, Seshadri S, Fernández-Cadenas I, Walters RG, Ruff CT, Owolabi MO, Huffman JE, Milani L, Kamatani Y, Dichgans M, Debette S.
Nature. 2022 Nov;611(7934):115-123. doi: 10.1038/s41586-022-05165-3.
Vaura F, Kim H, Udler MS; FinnGen*, Salomaa V, Lahti L, Niiranen T.
Circ Genom Precis Med. 2022 Aug;15(4):e003583. doi: 10.1161/CIRCGEN.121.003583.
Aittokallio J, Kauko A, Vaura F, Salomaa V, Kiviniemi T; FinnGen, Schnabel RB, Niiranen T.
Am J Cardiol. 2022 Mar 15;167:9-14. doi: 10.1016/j.amjcard.2021.11.046.
Sipeky, C., Tammela, T.L.J., Auvinen, A, Schleutker J.
Prostate Cancer Prostatic Dis (2021). https://doi.org/10.1038/s41391-021-00378-5.
Salosensaari A, Laitinen V, Havulinna AS, Meric G, Cheng S, Perola M, Valsta L, Alfthan G, Inouye M, Watrous JD, Long T, Salido RA, Sanders K, Brennan C, Humphrey GC, Sanders JG, Jain M, Jousilahti P, Salomaa V, Knight R, Lahti L, Niiranen T.
Nat Commun 12, 2671 (2021). https://doi.org/10.1038/s41467-021-22962-y
Aittokallio J, Kauko A, Palmu J; FinnGen, Niiranen T.
J Cardiothorac Vasc Anesth. 2021 Nov;35(11):3232-3240. doi: 10.1053/j.jvca.2021.03.039.
Vaura F, Kauko A, Suvila K, Havulinna AS, Mars N, Salomaa V, FinnGen, Cheng S, Niiranen T.
Hypertension. 2021 Apr;77(4):1119-1127. doi: 10.1161/HYPERTENSIONAHA.120.16471.
Rodriguez BAT, Bhan A, Beswick A, Elwood PC, Niiranen TJ, Salomaa V; FinnGen Study, Trégouët DA, Morange PE, Civelek M, Ben-Shlomo Y, Schlaeger T, Chen MH, Johnson AD.
Am J Hum Genet. 2020 Aug 6;107(2):211-221. doi: 10.1016/j.ajhg.2020.06.008.
Vuori MA, Laukkanen JA, Pietilä A, Havulinna AS, Kähönen M, Salomaa V, Niiranen TJ; FinnGen investigators.

Scand J Public Health. 2020 Feb;48(1):20-28. doi: 10.1177/1403494819847051.