About Us

Our group investigates the pathophysiology, prediction and treatment of breast cancer-related lymphedema. We study the tissue composition and gene expression of both normal and lymphedematous skin and adipose tissue, with a particular focus on immune cells. We use single-cell RNA sequencing, spectral flow cytometry and immunofluorescence staining to obtain a comprehensive view on which cellular and molecular mediators are responsible for the initiation of adipose deposition and fibrosis in lymphedema. We are also characterizing the changes that take place in lymphatic endothelial cells as lymphedema progresses.  Our aim is to clarify the pathophysiology of lymphedema and to pave the way for novel therapeutic approaches for this chronic and debilitating condition.

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