COINS

The COINS project was set out to evaluate brain insulin resistance in mild cognitive impairment and early Alzheimer´s disease (AD). The study is recruiting patients with mild cognitive impairment or early Alzheimer´s disease and also cognitive healthy age-matched controls. The participants will undergo whole-body ¹⁸F-FDG-PET imaging both in a fasting state and during a hyperinsulinemic euglucemic clamp to evaluate glucose metabolism in different organs, including the brain. ¹⁸F-FDG-PET during the hyperinsulinemic clamp enables evaluating insulin resistance in specific tissues of the body. Previous studies on AD animal models and on brain slices of individuals diagnosed with AD suggest that brain insulin resistance might play an important role in the neuropathological process of AD, but this phenomenon has not yet been studied in vivo in humans.

Funding: Finnish Medical Foundation, Diabetes Research Foundation, Finnish Governmental Research Funding (ERVA)