Publications

Selected Publications

2024

Ojala R, Widjaja N, Hentilä J, Jalo A, Helin JS, Nissinen TA, Jalava N, Oikonen V, Eskola O, Rajander J, Löyttyniemi E, Ivaska KK, Hannukainen JC. Evaluation of bone marrow glucose uptake and adiposity in male rats after diet and exercise intervention. Frontiers in Endocrinology (Lausanne). 2024 Jun 14;15:1422869. doi: 10.3389/fendo.2024.1422869.

Jalo A, Helin JS, Hentilä J, Nissinen TA, Honkala SM, Heiskanen MA, Löyttyniemi E, Malm T, AND Hannukainen JC. Mechanisms Leading to Increased Insulin-Stimulated Cerebral Glucose Uptake in Obesity and Insulin Resistance: A High-Fat Diet and Exercise Training Intervention PET Study with Rats (CROSRAT). Journal of Functional Morphology and Kinesiology, 2024; 9(2):58. https://doi.org/10.3390/jfmk9020058.

Helin S, Rajander J, Aromaa J, Arponen E, Helin JS, and Olof Solin. In-target Production of [¹¹C]CH4 from a Nitrogen/Hydrogen Gas Target as a Function of Beam Current, Irradiation Time, and Target Temperature. EJNMMI Radiopharmacy and Chemistry 2024, 9, 24. https://doi.org/10.1186/s41181-024-00255-1.

Alzghool O, Aarnio R, Helin JS, Wahlroos S, Keller T, Matilainen M, Solis J, Danon JJ, Kassiou M, Snellman A, Solin O, Rinne JO, and Haaparanta-Solin M. Glial reactivity in a mouse model of beta-amyloid deposition assessed by PET imaging of P2X7 receptor and TSPO using [¹¹C]SMW139 and [¹⁸F]F-DPA. EJNMMI Research 2024, 14, 15. https://doi.org/10.1186/s13550-024-01085-7.

Lithovius V, Lahdenpohja S, Ibrahim H, Saarimäki-Vire J, Uusitalo L, Montaser H, Mikkola K, Yim CB, Keller T, Rajander J, Balboa D, Barsby T, Solin O, Nuutila P, Grönroos TJ, Otonkoski T. Non-invasive quantification of stem cell-derived islet graft size and composition. Diabetologia. 2024 Sep;67(9):1912-1929. doi: 10.1007/s00125-024-06194-5. Epub 2024 Jun 14.

2023

Saha E, Shimochi S, Keller T, Eskola O, López-Picón F, Rajander J, Löyttyniemi E, Forsback S, Solin O, Grönroos TJ*, Parikka V*. Evaluation of PET imaging as a tool for detecting neonatal hypoxic-ischemic encephalopathy in a preclinical animal model. Experimental Neurology, online 30 December 2023, https://doi.org/10.1016/j.expneurol.2023.114673.

Tuominen S, Nissi L, Kukkula A, Routila J, Huusko T, Leivo I, Minn H, Irjala H, Löyttyniemi E, Ventelä S, Sundvall M*, Grönroos TJ*. TSPO is a potential independent prognostic factor associated with cellular respiration and p16 in head and neck squamous cell carcinoma. Front. Oncol. 13:1298333. https://doi.org/10.3389/fonc.2023.1298333. Online ahead of print.

Shimochi S, Ihalainen J, Parikka V, Kudomi N, Tolvanen T, Hietanen A, Kokkomäki E, Johansson S, Tsuji M, Kanaya S, Yatkin E, Grönroos TJ, Iida H. Small animal PET with spontaneous inhalation of 15O-labelled oxygen gases: Longitudinal assessment of cerebral oxygen metabolism in a rat model of neonatal hypoxic-ischaemic encephalopathy. J Cereb Blood Flow Metab. 2023 Dec 19:271678X231220691. https://doi.org/10.1177/0271678X231220691. Online ahead of print.

Jaakkola MK, Rantala M, Jalo A, Saari T, Hentilä J, Helin JS, Nissinen TA, Eskola O, Rajander J, Virtanen KA, Hannukainen JC, López-Picón F, and Klén R. Segmentation of dynamic total-body [18F]FDG PET images using unsupervised clustering. International Journal of Biomedical Imaging vol. 2023, Article ID 3819587, 13 pages, 2023. https://doi.org/10.1155/2023/3819587

Savisto N, Grönroos TJ, Oikonen V, Rajander J, Löyttyniemi E, Bergman J, Forsback S, Solin O, Haaparanta-Solin M. [18F]Fluoride uptake in various bone types and soft tissues in rat. EJNMMI Res 13, 21 (2023). doi: 10.1186/s13550-023-00969-4. PMID: 36913049

Pekkarinen L, Kantonen T, Oikonen V, Haaparanta-Solin M, Aarnio R, Dickens AM, von Eyken A, Latva-Rasku A, Dadson P, Kirjavainen AK, Rajander J, Kalliokoski K, Rönnemaa T, Nummenmaa L, Nuutila P. Lower abdominal adipose tissue cannabinoid type 1 receptor availability in young men with overweight. Obesity 31:1844-1858, 2023. https://doi.org/10.1002/oby.23770

de Lucas ÁG, Lamminmäki U, López-Picón FR. ImmunoPET Directed to the Brain: A New Tool for Preclinical and Clinical Neuroscience. Biomolecules. 2023; 13(1):164. PMID: 36671549

2022

Krzyczmonik A, Grafinger KE, Keller T, Pfeifer L, Forsback S, Haaparanta-Solin M, Gouverneur V, López-Picón F, Solin O. Evaluation of [¹⁸F]FMTEB in Sprague Dawley rats as a PET tracer for metabotropic glutamate receptor 5. Nucl Med Biol. 116–117 (2023) 108309 doi: 10.1016/j.nucmedbio.2022.108309. PMID: 36521341.

Bonvicini G, Syvänen S, Andersson KG, Haaparanta-Solin M, López-Picón F, Sehlin D. ImmunoPET imaging of amyloid-beta in a rat model of Alzheimer’s disease with a bispecific, brain-penetrating fusion protein. Transl Neurodegener. 2022 Dec 26;11(1):55. doi: 10.1186/s40035-022-00324-y. PMID: 36567338.

Sun L, Aarnio R, Herre EA, Kärnä S, Palani S, Virtanen H, Liljenbäck H, Virta J, Honkaniemi A, Oikonen V, Han C, Laurila S, Bucci M, Helin S, Yatkin E, Nummenmaa L, Nuutila P, Tang J, Roivainen A. [¹¹C]carfentanil PET imaging for studying the peripheral opioid system in vivo: effect of photoperiod on mu-opioid receptor availability in brown adipose tissue. Eur J Nucl Med Mol Imaging. 2022 Sep 27. doi: 10.1007/s00259-022-05969-5. PMID: 36166079.

Brumberg J, Aarnio R, Forsberg A, Marjamäki P, Kerstens V, Moein MM, Nag S, Wahlroos S, Kassiou M, Windhorst AD, Halldin C, Haaparanta-Solin M, Fazio P, Oikonen V, Rinne JO, Varrone A. Quantification of the purinergic P2X₇ receptor with [¹¹C]SMW139 improves through correction for brain-penetrating radiometabolites. J Cereb Blood Flow Metab. 2022 Sep 26:271678X221126830. doi: 10.1177/0271678X221126830. PMID: 36163685.

Snellman A, Ekblad LL, Koivumäki M, Lindgrén N, Tuisku J, Perälä M, Kallio L, Lehtonen R, Saunavaara V, Saunavaara J, Oikonen V, Aarnio R, Löyttyniemi E, Parkkola R, Karrasch M, Zetterberg H, Blennow K, Rinne JO. ASIC-E4: Interplay of Beta-Amyloid, Synaptic Density and Neuroinflammation in Cognitively Normal Volunteers With Three Levels of Genetic Risk for Late-Onset Alzheimer’s Disease – Study Protocol and Baseline Characteristics. Front Neurol. 2022 Feb 9;13:826423. doi: 10.3389/fneur.2022.826423. PMID: 35222254.

Cvrljevic AN, Butt U, Huhtinen K, Grönroos TJ, Böckelman C, Lassus H, Butzow R, Haglund C, Kaipio K, Arsiola T, Laajala TD, Connolly DC, Ristimäki A, Carpen O, Pouwels J, Westermarck J. Ovarian Cancers with Low CIP2A Tumor Expression Constitute an APR-246-Sensitive Disease Subtype. Mol Cancer Ther. 2022 Jul 5;21(7):1236-1245. doi: 10.1158/1535-7163.MCT-21-0622. PMID: 35364610.

Aarnio R, Alzghool OM, Wahlroos S, O’Brien-Brown J, Kassiou M, Solin O, Rinne JO, Forsback S, Haaparanta-Solin M. Novel plasma protein binding analysis method for a PET tracer and its radiometabolites: a case study with [11C]SMW139 to explain the high uptake of radiometabolites in mouse brain. J. Pharm. Biomed. Anal. 2022, May 28; 114860. https://doi.org/10.1016/j.jpba.2022.114860. Epub 2022 May 28. PMID: 35738120.

Shimochi S, Keller T, Kujala E, Khabbal J, Rajander J, Löyttyniemi E, Solin O, Nuutila P, Kanaya S, Yatkin E, Grönroos TJ, Iida H. Evaluation of [¹⁸F]F-DPA PET for Detecting Microglial Activation in the Spinal Cord of a Rat Model of Neuropathic Pain. Mol Imaging Biol. 2022 Aug;24(4):641-650. doi: 10.1007/s11307-022-01713-5. Epub 2022 Mar 18. PMID: 35303205

Alzghool OM, van Dongen G, van de Giessen E, Schoonmade L, Beaino W. α-Synuclein Radiotracer Development and In Vivo Imaging: Recent Advancements and New Perspectives. Mov Disord. 2022 Mar 15. doi: 10.1002/mds.28984. Epub ahead of print. PMID: 35289424.

Navarrete F, García-Gutiérrez MS, Gasparyan A, Navarro D, López-Picón F, Morcuende Á, Femenía T, Manzanares J. Biomarkers of the Endocannabinoid System in Substance Use Disorders. Biomolecules. 2022 Mar 3;12(3):396. doi: 10.3390/biom12030396. PMID: 35327588

Vainio SK, Dickens AM, Matilainen M, López-Picón FR, Aarnio R, Eskola O, Solin O, Anthony DC, Rinne JO, Airas L, Haaparanta-Solin M. Dimethyl fumarate decreases short-term but not long-term inflammation in a focal EAE model of neuroinflammation. EJNMMI Res. 2022 Feb 2;12(1):6. doi: 10.1186/s13550-022-00878-y. PMID: 35107664.

López-Picón FR, Keller T, Bocancea D, Helin JS, Krzyczmonik A, Helin S, Damont A, Dollé F, Rinne JO, Haaparanta-Solin M, Solin O. Direct Comparison of [¹⁸F]F-DPA with [¹⁸F]DPA-714 and [¹¹C]PBR28 for Neuroinflammation Imaging in the same Alzheimer’s Disease Model Mice and Healthy Controls. Mol Imaging Biol. 2022 Feb;24(1):157-166. doi: 10.1007/s11307-021-01646-5. Epub 2021 Sep 20. PMID: 34542805

2021

Tuominen S, Keller T, Petruk N, López-Picón F, Eichin D, Löyttyniemi E, Verhassel A, Rajander J, Sandholm J, Tuomela J, Grönroos TJ. Evaluation of [¹⁸F]F-DPA as a target for TSPO in head and neck cancer under normal conditions and after radiotherapy. Eur J Nucl Med Mol Imaging. 2021 May;48(5):1312-1326. doi: 10.1007/s00259-020-05115-z. Epub 2020 Dec 19. PMID: 33340054.

Raiko JRH, Saari T, Orava J, Savisto N, Parkkola R, Haaparanta-Solin M, Nuutila P, Virtanen KA. Changes in electrocardiogram parameters during acute nonshivering cold exposure and associations with brown adipose tissue activity, plasma catecholamine levels, and brachial blood pressure in healthy adults. Physiol Rep. 2021 Feb;9(3):e14718. doi: 10.14814/phy2.14718. PMID: 33580902.

Zhang L, Zhuang X, Kotitalo P, Keller T, Krzyczmonik A, Haaparanta-Solin M, Solin O, Forsback S, Grönroos TJ, Han C, López-Picón FR, Xia H. Intravenous transplantation of olfactory ensheathing cells reduces neuroinflammation after spinal cord injury via interleukin-1 receptor antagonist. Theranostics. 2021 Jan 1;11(3):1147-1161. doi: 10.7150/thno.52197. PMID: 33391526.

Alzghool OM, Rokka J, López-Picón FR, Snellman A, Helin JS, Okamura N, Solin O, Rinne JO, Haaparanta-Solin M. (S)-[¹⁸F]THK5117 brain uptake is associated with Aβ plaques and MAO-B enzyme in a mouse model of Alzheimer’s disease. Neuropharmacology. 2021 Jun 30;196:108676. doi: 10.1016/j.neuropharm.2021.108676. Epub ahead of print. PMID: 34216585.

Zhang L, López-Picón FR, Jia Y, Chen Y, Li J, Han C, Zhuang X, Xia H. Longitudinal [¹⁸F]FDG and [¹³N]NH₃ PET/CT imaging of brain and spinal cord in a canine hemisection spinal cord injury model. Neuroimage Clin. 2021 May 4;31:102692. doi: 10.1016/j.nicl.2021.102692. PMID: 33992987.

Laine S, Högel H, Ishizu T, Toivanen J, Yli-Karjanmaa M, Grönroos TJ, Rantala J, Mäkelä R, Hannukainen JC, Kalliokoski KK, Heinonen I. Effects of Different Exercise Training Protocols on Gene Expression of Rac1 and PAK1 in Healthy Rat Fast- and Slow-Type Muscles. Front Physiol. 2020 Nov 19;11:584661. doi: 10.3389/fphys.2020.584661. PMID: 33329033.

Chaney AM, Lopez-Picon FR, Serrière S, Wang R, Bochicchio D, Webb SD, Vandesquille M, Harte MK, Georgiadou C, Lawrence C, Busson J, Vercouillie J, Tauber C, Buron F, Routier S, Reekie T, Snellman A, Kassiou M, Rokka J, Davies KE, Rinne JO, Salih DA, Edwards FA, Orton LD, Williams SR, Chalon S, Boutin H. Prodromal neuroinflammatory, cholinergic and metabolite dysfunction detected by PET and MRS in the TgF344-AD transgenic rat model of AD: a collaborative multi-modal study. Theranostics. 2021 May 3;11(14):6644-6667. doi: 10.7150/thno.56059. PMID: 34093845.

Laine A, Nagelli SG, Farrington C, Butt U, Cvrljevic AN, Vainonen JP, Feringa FM, Grönroos TJ, Gautam P, Khan S, Sihto H, Qiao X, Pavic K, Connolly DC, Kronqvist P, Elo LL, Maurer J, Wennerberg K, Medema RH, Joensuu H, Peuhu E, de Visser K, Narla G, Westermarck J. CIP2A Interacts with TopBP1 and Drives Basal-Like Breast Cancer Tumorigenesis. Cancer Res. 2021 Aug 15;81(16):4319-4331. doi: 10.1158/0008-5472.CAN-20-3651. Epub 2021 Jun 18. PMID: 34145035.

Hyväkkä A, Virtanen V, Kemppainen J, Grönroos TJ, Minn H, Sundvall M. More Than Meets the Eye: Scientific Rationale behind Molecular Imaging and Therapeutic Targeting of Prostate-Specific Membrane Antigen (PSMA) in Metastatic Prostate Cancer and Beyond. Cancers (Basel). 2021 May 7;13(9):2244. doi: 10.3390/cancers13092244. PMID: 34067046.

2020

Lahdenpohja S, Rajala NA, Helin JS, Haaparanta-Solin M, Solin O, López-Picón FR, Kirjavainen AK. Ruthenium-Mediated ¹⁸F-Fluorination and Preclinical Evaluation of a New CB₁ Receptor Imaging Agent [¹⁸F]FPATPP. ACS Chem Neurosci. 2020 Jul 1;11(13):2009-2018. doi: 10.1021/acschemneuro.0c00313. Epub 2020 Jun 16. PMID: 32479723.

Keller T, López-Picón FR, Krzyczmonik A, Forsback S, Takkinen JS, Rajander J, Teperi S, Dollé F, Rinne JO, Haaparanta-Solin M, Solin O. Comparison of high and low molar activity TSPO tracer [¹⁸F]F-DPA in a mouse model of Alzheimer’s disease. J Cereb Blood Flow Metab. 2020 May;40(5):1012-1020. doi: 10.1177/0271678X19853117. Epub 2019 May 29. PMID: 31142224.

Saari TJ, Raiko J, U-Din M, Niemi T, Taittonen M, Laine J, Savisto N, Haaparanta-Solin M, Nuutila P, Virtanen KA. Basal and cold-induced fatty acid uptake of human brown adipose tissue is impaired in obesity. Sci Rep. 2020 Sep 1;10(1):14373. doi: 10.1038/s41598-020-71197-2. PMID: 32873825.

Teuho J, Riehakainen L, Honkaniemi A, Moisio O, Han C, Tirri M, Liu S, Grönroos TJ, Liu J, Wan L, Liang X, Ling Y, Hua Y, Roivainen A, Knuuti J, Xie Q, Teräs M, D’Ascenzo N, Klén R. Evaluation of image quality with four positron emitters and three preclinical PET/CT systems. EJNMMI Res. 2020 Dec 10;10(1):155. doi: 10.1186/s13550-020-00724-z. PMID: 33301074.

Laukka M, Hoppela E, Salo J, Rantakari P, Gronroos TJ, Orte K, Auvinen K, Salmi M, Gerke H, Thol K, Peuhu E, Kauhanen S, Merilahti P, Hartiala P. Preperitoneal Fat Grafting Inhibits the Formation of Intra-abdominal Adhesions in Mice. J Gastrointest Surg. 2020 Dec;24(12):2838-2848. doi: 10.1007/s11605-019-04425-4. Epub 2019 Dec 10. PMID: 31823326.

2019

Krzyczmonik A, Keller T, López-Picón FR, Forsback S, Kirjavainen AK, Takkinen JS, Wasilewska A, Scheinin M, Haaparanta-Solin M, Sączewski F, Solin O. Radiosynthesis and Preclinical Evaluation of an α_2A-Adrenoceptor Tracer Candidate, 6-[¹⁸F]Fluoro-marsanidine. Mol Imaging Biol. 2019 Oct;21(5):879-887. doi: 10.1007/s11307-019-01317-6. PMID: 30710261.

López-Picón FR, Kirjavainen AK, Forsback S, Takkinen JS, Peters D, Haaparanta-Solin M, Solin O. In vivo characterization of a novel norepinephrine transporter PET tracer [¹⁸F]NS12137 in adult and immature Sprague-Dawley rats. Theranostics. 2019 Jan 1;9(1):11-19. doi: 10.7150/thno.29740. PMID: 30662550.

Snellman A, Takkinen JS, López-Picón FR, Eskola O, Solin O, Rinne JO, Haaparanta-Solin M. Effect of genotype and age on cerebral [¹⁸F]FDG uptake varies between transgenic APP_Swe-PS1_dE9 and Tg2576 mouse models of Alzheimer’s disease. Sci Rep. 2019 Apr 5;9(1):5700. doi: 10.1038/s41598-019-42074-4. PMID: 30952945.

Grönroos TJ, Forsback S, Eskola O, Bergman J, Marjamäki P, Löyttyniemi E, Hietala J, Haaparanta-Solin M, Solin O. [¹⁸F]SPA-RQ/PET Study of NK1 receptors in the Whole Body of Guinea Pig and Rat. Sci Rep. 2019 Dec 31;9(1):20412. doi: 10.1038/s41598-019-56848-3. PMID: 31892711.

Kähkönen TE, Tuomela JM, Grönroos TJ, Halleen JM, Ivaska KK, Härkönen PL. Dovitinib dilactic acid reduces tumor growth and tumor-induced bone changes in an experimental breast cancer bone growth model. J Bone Oncol. 2019 Mar 19;16:100232. doi: 10.1016/j.jbo.2019.100232. PMID: 30956945.

Laurikainen H, Tuominen L, Tikka M, Merisaari H, Armio RL, Sormunen E, Borgan F, Veronese M, Howes O, Haaparanta-Solin M, Solin O, Hietala J; METSY group. Sex difference in brain CB1 receptor availability in man. Neuroimage. 2019 Jan 1;184:834-842. doi: 10.1016/j.neuroimage.2018.10.013. Epub 2018 Oct 5. PMID: 30296558.

Vainio SK, Dickens AM, Tuisku J, Eskola O, Solin O, Löyttyniemi E, Anthony DC, Rinne JO, Airas L, Haaparanta-Solin M. Cessation of anti-VLA-4 therapy in a focal rat model of multiple sclerosis causes an increase in neuroinflammation. EJNMMI Res. 2019 May 9;9(1):38. doi: 10.1186/s13550-019-0508-7. PMID: 31073768.

Borgan F, Laurikainen H, Veronese M, Marques TR, Haaparanta-Solin M, Solin O, Dahoun T, Rogdaki M, Salokangas RK, Karukivi M, Di Forti M, Turkheimer F, Hietala J, Howes O; METSY Group. In Vivo Availability of Cannabinoid 1 Receptor Levels in Patients With First-Episode Psychosis. JAMA Psychiatry. 2019 Oct 1;76(10):1074-1084. doi: 10.1001/jamapsychiatry.2019.1427. PMID: 31268519.

Motiani KK, Savolainen AM, Toivanen J, Eskelinen JJ, Yli-Karjanmaa M, Virtanen KA, Saunavaara V, Heiskanen MA, Parkkola R, Haaparanta-Solin M, Solin O, Savisto N, Löyttyniemi E, Knuuti J, Nuutila P, Kalliokoski KK, Hannukainen JC. Effects of short-term sprint interval and moderate-intensity continuous training on liver fat content, lipoprotein profile, and substrate uptake: a randomized trial. J Appl Physiol (1985). 2019 Jun 1;126(6):1756-1768. doi: 10.1152/japplphysiol.00900.2018. Epub 2019 Apr 18. PMID: 30998125.

2018

Tolmachev V, Grönroos TJ, Yim CB, Garousi J, Yue Y, Grimm S, Rajander J, Perols A, Haaparanta-Solin M, Solin O, Ferdani R, Orlova A, Anderson CJ, Karlström AE. Molecular design of radiocopper-labelled Affibody molecules. Sci Rep. 2018 Apr 25;8(1):6542. doi: 10.1038/s41598-018-24785-2. PMID: 29695813.

Kirjavainen AK, Forsback S, López-Picón FR, Marjamäki P, Takkinen J, Haaparanta-Solin M, Peters D, Solin O. ¹⁸F-labeled norepinephrine transporter tracer [¹⁸F]NS12137: radiosynthesis and preclinical evaluation. Nucl Med Biol. 2018 Jan;56:39-46. doi: 10.1016/j.nucmedbio.2017.10.005. Epub 2017 Oct 24. PMID: 29172120.

Lahesmaa M, Eriksson O, Gnad T, Oikonen V, Bucci M, Hirvonen J, Koskensalo K, Teuho J, Niemi T, Taittonen M, Lahdenpohja S, U Din M, Haaparanta-Solin M, Pfeifer A, Virtanen KA, Nuutila P. Cannabinoid Type 1 Receptors Are Upregulated During Acute Activation of Brown Adipose Tissue. Diabetes. 2018 Jul;67(7):1226-1236. doi: 10.2337/db17-1366. Epub 2018 Apr 12. PMID: 29650773.

Keller T, López-Picón FR, Krzyczmonik A, Forsback S, Kirjavainen AK, Takkinen JS, Alzghool O, Rajander J, Teperi S, Cacheux F, Damont A, Dollé F, Rinne JO, Solin O, Haaparanta-Solin M. [¹⁸F]F-DPA for the detection of activated microglia in a mouse model of Alzheimer’s disease. Nucl Med Biol. 2018 Dec;67:1-9. doi: 10.1016/j.nucmedbio.2018.09.001. Epub 2018 Sep 26. PMID: 30317069.

López-Picón FR, Snellman A, Eskola O, Helin S, Solin O, Haaparanta-Solin M, Rinne JO. Neuroinflammation Appears Early on PET Imaging and Then Plateaus in a Mouse Model of Alzheimer Disease. J Nucl Med. 2018 Mar;59(3):509-515. doi: 10.2967/jnumed.117.197608. Epub 2017 Oct 6. PMID: 28986511.

Leinonen V, Rauramaa T, Johansson J, Bottelbergs A, Tesseur I, van der Ark P, Pemberton D, Koivisto AM, Jääskeläinen JE, Hiltunen M, Herukka SK, Blennow K, Zetterberg H, Jokinen P, Rokka J, Helin S, Haaparanta-Solin M, Solin O, Okamura N, Kolb HC, Rinne JO. S-[18F]THK-5117-PET and [11C]PIB-PET Imaging in Idiopathic Normal Pressure Hydrocephalus in Relation to Confirmed Amyloid-β Plaques and Tau in Brain Biopsies. J Alzheimers Dis. 2018;64(1):171-179. doi: 10.3233/JAD-180071. PMID: 29865068.

Takkinen JS, López-Picón FR, Kirjavainen AK, Pihlaja R, Snellman A, Ishizu T, Löyttyniemi E, Solin O, Rinne JO, Haaparanta-Solin M. [¹⁸F]FMPEP-d₂ PET imaging shows age- and genotype-dependent impairments in the availability of cannabinoid receptor 1 in a mouse model of Alzheimer’s disease. Neurobiol Aging. 2018 Sep;69:199-208. doi: 10.1016/j.neurobiolaging.2018.05.013. Epub 2018 May 18. PMID: 29909177.

Hoppela E, Grönroos TJ, Saarikko AM, Tervala TV, Kauhanen S, Nuutila P, Kivinen K, Hartiala P. Fat Grafting Can Induce Browning of White Adipose Tissue. Plast Reconstr Surg Glob Open. 2018 Jun 19;6(6):e1804. doi: 10.1097/GOX.0000000000001804. PMID: 30276049.

Silvoniemi A, Suilamo S, Laitinen T, Forsback S, Löyttyniemi E, Vaittinen S, Saunavaara V, Solin O, Grönroos TJ, Minn H. Repeatability of tumour hypoxia imaging using [¹⁸F]EF5 PET/CT in head and neck cancer. Eur J Nucl Med Mol Imaging. 2018 Feb;45(2):161-169. doi: 10.1007/s00259-017-3857-3. Epub 2017 Oct 26. PMID: 29075831.

2017

Rokka J, Grönroos TJ, Viljanen T, Solin O, Haaparanta-Solin M. HPLC and TLC methods for analysis of [¹⁸F]FDG and its metabolites from biological samples. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Mar 24;1048:140-149. doi: 10.1016/j.jchromb.2017.01.042. Epub 2017 Feb 9. PMID: 28236580.

Motiani KK, Savolainen AM, Eskelinen JJ, Toivanen J, Ishizu T, Yli-Karjanmaa M, Virtanen KA, Parkkola R, Kapanen J, Grönroos TJ, Haaparanta-Solin M, Solin O, Savisto N, Ahotupa M, Löyttyniemi E, Knuuti J, Nuutila P, Kalliokoski KK, Hannukainen JC. Two weeks of moderate-intensity continuous training, but not high-intensity interval training, increases insulin-stimulated intestinal glucose uptake. J Appl Physiol (1985). 2017 May 1;122(5):1188-1197. doi: 10.1152/japplphysiol.00431.2016. Epub 2017 Feb 9. PMID: 28183816.

Tolmachev V, Yim CB, Rajander J, Perols A, Karlström AE, Haaparanta-Solin M, Grönroos TJ, Solin O, Orlova A. Comparative Evaluation of Anti-HER2 Affibody Molecules Labeled with ⁶⁴Cu Using NOTA and NODAGA. Contrast Media Mol Imaging. 2017 Feb 28;2017:8565802. doi: 10.1155/2017/8565802. PMID: 29097939.

Snellman A, Rokka J, López-Picón FR, Helin S, Re F, Löyttyniemi E, Pihlaja R, Forloni G, Salmona M, Masserini M, Solin O, Rinne JO, Haaparanta-Solin M. Applicability of [¹¹C]PIB micro-PET imaging for in vivo follow-up of anti-amyloid treatment effects in APP23 mouse model. Neurobiol Aging. 2017 Sep;57:84-94. doi: 10.1016/j.neurobiolaging.2017.05.008. Epub 2017 May 15. PMID: 28605642.

Takkinen JS, López-Picón FR, Al Majidi R, Eskola O, Krzyczmonik A, Keller T, Löyttyniemi E, Solin O, Rinne JO, Haaparanta-Solin M. Brain energy metabolism and neuroinflammation in ageing APP/PS1-21 mice using longitudinal ¹⁸F-FDG and ¹⁸F-DPA-714 PET imaging. J Cereb Blood Flow Metab. 2017 Aug;37(8):2870-2882. doi: 10.1177/0271678X16677990. Epub 2016 Jan 1. PMID: 27834284.

Keller T, Krzyczmonik A, Forsback S, Picón FRL, Kirjavainen AK, Takkinen J, Rajander J, Cacheux F, Damont A, Dollé F, Rinne JO, Haaparanta-Solin M, Solin O. Radiosynthesis and Preclinical Evaluation of [¹⁸F]F-DPA, A Novel Pyrazolo[1,5a]pyrimidine Acetamide TSPO Radioligand, in Healthy Sprague Dawley Rats. Mol Imaging Biol. 2017 Oct;19(5):736-745. doi: 10.1007/s11307-016-1040-z. PMID: 28083825.

Pihlaja R, Haaparanta-Solin M, Rinne JO. The Anti-Inflammatory Effects of Lipoxygenase and Cyclo-Oxygenase Inhibitors in Inflammation-Induced Human Fetal Glia Cells and the Aβ Degradation Capacity of Human Fetal Astrocytes in an Ex vivo Assay. Front Neurosci. 2017 May 30;11:299. doi: 10.3389/fnins.2017.00299. PMID: 28611577.

Pihlasalo S, Deguchi T, Virtamo M, Jacobino J, Chary K, López-Picón FR, Brunhofer-Bolzer G, Huttunen R, Fallarero A, Vuorela P, Härmä H. Luminometric Nanoparticle-Based Assay for High Sensitivity Detection of β-Amyloid Aggregation. Anal Chem. 2017 Feb 21;89(4):2398-2404. doi: 10.1021/acs.analchem.6b04266. Epub 2017 Feb 2. PMID: 28219250.

2016

López-Picón F, Snellman A, Shatillo O, Lehtiniemi P, Grönroos TJ, Marjamäki P, Trigg W, Jones PA, Solin O, Pitkänen A, Haaparanta-Solin M. Ex Vivo Tracing of NMDA and GABA-A Receptors in Rat Brain After Traumatic Brain Injury Using 18F-GE-179 and 18F-GE-194 Autoradiography. J Nucl Med. 2016 Sep;57(9):1442-7. doi: 10.2967/jnumed.115.167403. Epub 2016 May 19. PMID: 27199360.

van Dijk LK, Yim CB, Franssen GM, Kaanders JH, Rajander J, Solin O, Grönroos TJ, Boerman OC, Bussink J. PET of EGFR with (64) Cu-cetuximab-F(ab’)2 in mice with head and neck squamous cell carcinoma xenografts. Contrast Media Mol Imaging. 2016 Jan-Feb;11(1):65-70. doi: 10.1002/cmmi.1659. Epub 2015 Aug 4. PMID: 26242487.

Jadhav S, Yim CB, Rajander J, Grönroos TJ, Solin O, Virta P. Solid-Supported Porphyrins Useful for the Synthesis of Conjugates with Oligomeric Biomolecules. Bioconjug Chem. 2016 Apr 20;27(4):1023-9. doi: 10.1021/acs.bioconjchem.6b00051. Epub 2016 Mar 9. PMID: 26898631.

Golla SS, Boellaard R, Oikonen V, Hoffmann A, van Berckel BN, Windhorst AD, Virta J, Te Beek ET, Groeneveld GJ, Haaparanta-Solin M, Luoto P, Savisto N, Solin O, Valencia R, Thiele A, Eriksson J, Schuit RC, Lammertsma AA, Rinne JO. Parametric Binding Images of the TSPO Ligand 18F-DPA-714. J Nucl Med. 2016 Oct;57(10):1543-1547. doi: 10.2967/jnumed.116.173013. Epub 2016 Jun 3. PMID: 27261521.

Rokka J, Snellman A, Kaasalainen M, Salonen J, Zona C, La Ferla B, Nicotra F, Re F, Masserini M, Forsback S, Lopez-Picon F, Rinne JO, Haaparanta-Solin M, Solin O. (18)F-labeling syntheses and preclinical evaluation of functionalized nanoliposomes for Alzheimer’s disease. Eur J Pharm Sci. 2016 Jun 10;88:257-66. doi: 10.1016/j.ejps.2016.03.016. Epub 2016 Mar 16. PMID: 26993963.

Asser A, Kõks S, Snellman A, Haaparanta-Solin M, Arponen E, Grönroos T, Nairismägi J, Bergquist J, Soomets U, Piip P, Eltermaa M, Sauk M, Lindmäe H, Rinne JO, Taba P. Increased striatal VMAT2 binding in mice after chronic administration of methcathinone and manganese. Brain Res. 2016 Dec 1;1652:97-102. doi: 10.1016/j.brainres.2016.09.034. Epub 2016 Sep 28. PMID: 27693414.

2015

Eriksson O, Mikkola K, Espes D, Tuominen L, Virtanen K, Forsbäck S, Haaparanta-Solin M, Hietala J, Solin O, Nuutila P. The Cannabinoid Receptor-1 Is an Imaging Biomarker of Brown Adipose Tissue. J Nucl Med. 2015 Dec;56(12):1937-41. doi: 10.2967/jnumed.115.156422. Epub 2015 Sep 10. PMID: 26359260.

Pihlaja R, Takkinen J, Eskola O, Vasara J, López-Picón FR, Haaparanta-Solin M, Rinne JO. Monoacylglycerol lipase inhibitor JZL184 reduces neuroinflammatory response in APdE9 mice and in adult mouse glial cells. J Neuroinflammation. 2015 Apr 28;12:81. doi: 10.1186/s12974-015-0305-9. PMID: 25927213.

Varrone A, Oikonen V, Forsberg A, Joutsa J, Takano A, Solin O, Haaparanta-Solin M, Nag S, Nakao R, Al-Tawil N, Wells LA, Rabiner EA, Valencia R, Schultze-Mosgau M, Thiele A, Vollmer S, Dyrks T, Lehmann L, Heinrich T, Hoffmann A, Nordberg A, Halldin C, Rinne JO. Positron emission tomography imaging of the 18-kDa translocator protein (TSPO) with [18F]FEMPA in Alzheimer’s disease patients and control subjects. Eur J Nucl Med Mol Imaging. 2015 Mar;42(3):438-46. doi: 10.1007/s00259-014-2955-8. Epub 2014 Nov 21. PMID: 25412766.

Golla SS, Boellaard R, Oikonen V, Hoffmann A, van Berckel BN, Windhorst AD, Virta J, Haaparanta-Solin M, Luoto P, Savisto N, Solin O, Valencia R, Thiele A, Eriksson J, Schuit RC, Lammertsma AA, Rinne JO. Quantification of [18F]DPA-714 binding in the human brain: initial studies in healthy controls and Alzheimer’s disease patients. J Cereb Blood Flow Metab. 2015 May;35(5):766-72. doi: 10.1038/jcbfm.2014.261. Epub 2015 Feb 4. PMID: 25649991.

Bucci M, Karmi AC, Iozzo P, Fielding BA, Viljanen A, Badeau RM, Borra R, Saunavaara V, Pham T, Hannukainen JC, Kalliokoski K, Haaparanta-Solin M, Viljanen T, Parkkola R, Frayn KN, Nuutila P. Enhanced fatty acid uptake in visceral adipose tissue is not reversed by weight loss in obese individuals with the metabolic syndrome. Diabetologia. 2015 Jan;58(1):158-64. doi: 10.1007/s00125-014-3402-x. Epub 2014 Oct 21. PMID: 25331375.

Airas L, Dickens AM, Elo P, Marjamäki P, Johansson J, Eskola O, Jones PA, Trigg W, Solin O, Haaparanta-Solin M, Anthony DC, Rinne J. In vivo PET imaging demonstrates diminished microglial activation after fingolimod treatment in an animal model of multiple sclerosis. J Nucl Med. 2015 Feb;56(2):305-10. doi: 10.2967/jnumed.114.149955. Epub 2015 Jan 8. Erratum in: J Nucl Med. 2015 Mar;56(3):495. Erratum in: J Nucl Med. 2019 Apr;60(4):529. PMID: 25572093.