Data on the role of NFATC1 phosphorylation published

In our article published Nov 15, 2019 in Cell Communication and Signaling, we describe identification and functional validation of ten PIM1 phosphorylation target sites in the regulatory region of the NFATC1 transcription factor. We also show that phosphorylation of these sites is essential both for the transcriptional activity and for the pro-migratory effects of NFATC1 in prostate cancer cells. In addition, we have identified several NFATC1 target genes, the expression of which is enhanced in a PIM-dependent fashion and which may contribute to cancer cell migration, adhesion and invasion.

https://biosignaling.biomedcentral.com/articles/10.1186/s12964-019-0463-y