Recent publications

2023

Paavanen-Huhtala S, Kalichamy K, Pessi AM, Häkkilä S, Saarto A, Tuomela M, Andersson MA & Koskinen PJ. Biomonitoring of indoor air fungal or chemical toxins with Caenorhabditis elegans nematodes. Pathogens, 12, 161, 2023. https://www.mdpi.com/2076-0817/12/2/161

Mung KL, Meinander A & Koskinen PJ. PIM kinases phosphorylate lactate dehydrogenase A at serine 161 and suppress its nuclear ubiquitination. FEBS J. 290, 2489-2502, 2023. https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.16653

 

2021

Mung KL, Eccleshall W, Santio NM, Rivero-Müller A & Koskinen PJ. PIM kinases inhibit AMPK activation and promote tumorigenicity by phosphorylating LKB1. Cell Commun Signal 19, 68, 2021. https://biosignaling.biomedcentral.com/articles/10.1186/s12964-021-00749-4

Eerola SK, Kohvakka AM, Leinonen KA, Tammela TJ, Koskinen PJ, Latonen L & Visakorpi T. Expression and ERG-regulation of PIM kinases in prostate cancer. Cancer Medicine 10, 3427-3436, 2021. https://onlinelibrary.wiley.com/doi/10.1002/cam4.3893

Landor SKJ, Santio NM, Eccleshall WB, Paramonov VM, Gagliani EK, Hall D, Jin SB, Dahlström KM, Salminen TA, Rivero-Müller, Lendahl U, Kovall RA, Koskinen PJ & Sahlgren C. PIM-induced phosphorylation of Notch3 promotes breast cancer tumorigenicity in a CSL-independent fashion. J Biol Chem 296, 100593, 2021. https://www.sciencedirect.com/science/article/pii/S0021925821003732?via%3Dihub

2020

Santio NM, Vainio V, Hoikkala T, Mung KL, Lång M, Vahakoski R, Zdrojewska J, Coffey E, Kremneva E, Rainio EM & Koskinen PJ. PIM1 accelerates prostate cancer cell motility by phosphorylating actin capping proteins. Cell Commun Signal 18, 121, 2020. PMID: 32771000

Valta M, Ylä-Pelto J, Lan Y, Kähkönen T, Taimen P, Boström PJ, Ettala O, Khan S, Paulin N, Elo LL, Koskinen PJ, Härkönen P & Tuomela J. Critical evaluation of the subcutaneous engraftments of hormone naïve primary prostate cancer. Transl Androl Urol 9, 1120-1134, 2020. PMID: 32676396

2019

Eerola SK, Santio NM, Rinne S, Kouvonen P, Corthals G, Scaravilli M, Scala G, Serra A, Greco D, Ruusuvuori P, Latonen L, Rainio EM, Visakorpi T, Koskinen PJ. Phosphorylation of NFATC1 at PIM1 target sites is essential for its ability to promote prostate cancer cell migration and invasion. Cell Commun Signal 17, 148, 2019. PMID: 31730483

Kalichamy K, Ikkala K, Pörsti J, Santio NM, Jha S, Holmberg CI, Koskinen PJ. PIM-related kinases selectively regulate olfactory sensations in C. elegans. eNeuro 6, 1-13, 2019. PMID: 31387876

Kopra K, Tong-Ochoa N, Laine M, Eskonen V, Koskinen PJ, Härmä H. Homogeneous peptide-break assay for luminescent detection of enzymatic protein post-translational modification activity utilizing charged peptides. Anal Chim Acta, 1055, 126-132, 2019. PMID: 30782363​

Paavanen-Huhtala S, Andersson MA, Koskinen PJ. Terveydelle haitallisten sisäilman kemikaalien biomonitorointi sukkulamatojen avulla. Sisäilmastoseminaari, SIY raportti 37:429-432, 2019. (written in Finnish, title in English: Biomonitoring of hazardous indoor air chemicals with C. elegans nematodes)

2018

Santio NM, Koskinen PJ. PIM-kinaasit syövän etenemisen säätelijöinä ja lääkekehityskohteina. Duodecim 134, 1933-1940, 2018. (written in Finnish, title in English: PIM kinases as promoters of cancer progression and as drug targets)

Paavanen-Huhtala S, Kalichamy K, Pessi AM, Häkkilä S, Saarto A, Mikkola R, Andersson MA, Koskinen PJ. Mikrobien tuottamien toksiinien biomonitorointi sukkulamatojen avulla. Sisäilmastoseminaari, SIY raportti 36, 301-306, 2018. (written in Finnish, title in English: Biomonitoring of microbial toxins with C. elegans nematodes)

2017

Santio NM, Koskinen PJ. PIM kinases: From survival factors to regulators of cell motility. Int J Biochem Cell Biol, 93, 74-85, 2017. PMID: 29108877​

Kiriazis A, Aumüller IB, Arnaudova R, Brito V, Rüffer T, Lang H, Silvestre SM, Koskinen PJ, Yli-Kauhaluoma J. Nucleophilic substitution of hydrogen facilitated by quinone methide moieties in benzo[cd]azulen-3-ones. Org Lett, 19, 2030-2033, 2017. PMID: 28379712​

Paavanen-Huhtala S, Kalichamy K, Häkkilä S, Pessi AM, Saarto A, Koskinen P. Sukkulamadot sisäilmaongelmien bioindikaattoreina. Sisäilmastoseminaari, SIY raportti 35, 251-255, 2017. (written in Finnish, title in English: C. elegans nematodes as bioindicators for indoor air problems)

2016

Santio NM, Landor SKJ, Vahtera L, Ylä-Pelto J, Paloniemi E, Imanishi SY, Gorthals G, Varjosalo M, Manoharan G, Uri A, Lendahl U, Sahlgren C & Koskinen PJ. Phosphorylation of Notch1 by Pim kinases promotes oncogenic signaling in breast and prostate cancer cells. Oncotarget, 7, 43220-43238, 2016. PMID: 27281612

Santio NM, Salmela M, Arola H, Eerola SK, Heino J, Rainio EM, Koskinen PJ. The PIM1 kinase promotes prostate cancer cell migration and adhesion via multiple signalling pathways. Exp Cell Res, 342, 113-124, 2016. PIMID: 26934497

2015

Santio NM, Eerola SK, Paatero I, Yli-Kauhaluoma J, Anizon F, Moreau P, Tuomela J, Härkönen P, Koskinen PJ. Pim kinases promote migration and metastatic growth of prostate cancer xenografts. PLoS ONE 10, e0130340, 2015. PMID: 26075720​

2013

Kiriazis A, Vahakoski RL, Santio NM, Arnaudova R, Eerola SK, Rainio EM, Aumüller IB, Yli-Kauhaluoma J, Koskinen PJ. Tricyclic benzo[cd]azulenes selectively inhibit activities of Pim kinases and restrict growth of Epstein-Barr virus-transformed cells. PLoS ONE 8, e55409, 2013. PMID: 23405147

​Tahvanainen J, Kyläniemi MK, Kanduri K, Gupta B, Lähteenmäki H, Kallonen T, Rajavuori A, Rasool O, Koskinen PJ, Rao KV, Lähdesmäki H, Lahesmaa R. Proviral integration site for Moloney murine leukemia virus (PIM) kinases promote T helper 1 cell differentiation. J. Biol. Chem. 288,3048-3058, 2013. PMID: 23209281

Sarek G, Ma L, Enbäck J, Järviluoma A, Moreau P, Haas J, Gessain A, Koskinen PJ, Laakkonen P & Ojala PM. Kaposi´s sarcoma herpesvirus lytic replication compromises apoptotic response to p53 reactivation in virus-induced lymphomas. Oncogene 32, 1091-1098, 2013. PMID: 22469985

2012

Letribot B, Akué-Gédu R, Santio NM, El-Ghozzi M, Avignant D, Cisnetti F, Koskinen PJ, Gautier A, Anizon F & Moreau P. Use of copper(I) catalyzed azide alkyne cycloaddition (CuAAC) for the preparation of conjugated pyrrolo[2,3-a]carbazole Pim kinase inhibitors. Eur. J. Med. Chem. 50, 304-310, 2012. PMID: 22386260

2011

Kouvonen P, Rainio EM, Suni V, Koskinen P & Corthals G. Enrichment and sequencing of phosphopeptides using indium tin oxide coated glass slides. Mol. BioSyst. 7, 1828-1837, 2011. PMID: 21523302

2010

Santio NM, Vahakoski RL, Rainio EM, Sandholm JA, Virtanen SS, Prudhomme M, Anizon F, Moreau P & Koskinen PJ. Pim-selective inhibitor DHPCC-9 reveals Pim kinases as potent stimulators of cancer cell migration and invasion. Mol. Cancer 9, 279, 2010. PMID: 20958956

Kouvonen P, Rainio EM, Suni V, Koskinen P & Corthals G. Data combination from multiple matrix-assisted laser desorption/ionization (MALDI) matrices: opportunities and limitations for MALDI analysis. Rapid Commun. Mass Spectrom. 24, 1-3, 2010. PMID: 21072807

2009

Peltola KJ, Hollmén M, Maula SM, Rainio EM, Ristamäki R, Luukkaa M, Sandholm J, Sundvall M, Elenius K, Koskinen PJ, Grenman R & Jalkanen S. Pim-1 kinase expression predicts radiation response in squamocellular carcinoma of head and neck and is under the control of epidermal growth factor receptor. Neoplasia 11, 629-636, 2009. PMID: 19568408

Cheng F, Weidner-Glunde M, Varjosalo M, Rainio EM, Lehtonen A, Schulz TF, Koskinen PJ, Taipale J & Ojala PM. KSHV reactivation from latency requires Pim-1 and Pim-3 kinases to inactivate the latency-associated nuclear antigen LANA. PLoS Pathogens, 5, e1000324, 2009. 19266083​