PIM kinases shown to regulate estrogen-dependent signaling

Our recent data indicate that estrogen receptor (ER) alpha is a novel substrate for PIM kinases. Via phosphorylation of serine 167 in the activation function domain of ER alpha, PIM kinases stimulate expression of ER target genes in luminal a breast cancer cells, while lack of PIM expression or activity restricts ER-dependent signaling.

https://www.preprints.org/manuscript/202409.0907/v1