Publications

Selected publications

Houttu N, Mokkala K, Koivuniemi E, Pellonperä O, Juhila J, Sorsa T, Laitinen K. The impacts of fish oil and/or probiotic intervention on low-grade inflammation, IGFBP-1 and MMP-8 in pregnancy: A randomized, placebo-controlled, double-blind clinical trial. Biomolecules 2021, 11(1), 5; (published online: December 22, 2020).
PubMed: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822218/

Pellonperä O, Vahlberg T, Mokkala K, Houttu N, Koivuniemi E, Tertti T, Rönnemaa T, Laitinen K. Weight gain and body composition during pregnancy: a randomized pilot trial with probiotics and/or fish oil. Brit J Nutr 2020 (published online: November 4, 2020).
PubMed: https://pubmed.ncbi.nlm.nih.gov/33143755/

Mokkala K, Juhila J, Houttu N, Sorsa T, Laitinen K. Early pregnancy serum IGFBP-1 relates to lipid profile in overweight and obese women. Heliyon 2020;6: e04788.
PubMed: https://pubmed.ncbi.nlm.nih.gov/32923723/

Gerdes V, Gueimonde M, Pajunen L, Nieuwdorp M, Laitinen K. How strong is the evidence that gut microbiota composition can be influenced by lifestyle interventions in a cardio-protective way? Atherosclerosis 2020.
PubMed: https://pubmed.ncbi.nlm.nih.gov/32981713/ 

Mokkala K, Paulin N, Houttu N, et al. Metagenomics analysis of gut microbiota in response to diet intervention and gestational diabetes in overweight and obese women: a randomised, double-blind, placebo-controlled clinical trial. Gut. Published Online First: 24 August 2020a.
PubMed: https://pubmed.ncbi.nlm.nih.gov/32839200/

Mokkala K, Vahlberg T, Houttu N, Koivuniemi E, Laitinen K. Distinct Metabolomic Profile Because of Gestational Diabetes and its Treatment Mode in Women with Overweight and Obesity. Obesity (Silver Spring). 2020b;28(9):1637-1644.
PubMed: https://pubmed.ncbi.nlm.nih.gov/32705820/

Mokkala K, Vahlberg T, Pellonperä O, Houttu N, Koivuniemi E, Laitinen K. Distinct Metabolic Profile in Early Pregnancy of Overweight and Obese Women Developing Gestational Diabetes. J Nutr. 2020c;150(1):31–37.

Mokkala K, Houttu N, Koivuniemi E, Sørensen N, Nielsen HB, Laitinen K. GlycA, a novel marker for low grade inflammation, reflects gut microbiome diversity and is more accurate than high sensitive CRP in reflecting metabolomic profile. Metabolomics. 2020d;16(7):76. Published 2020 Jun 20.
PubMed: https://pubmed.ncbi.nlm.nih.gov/32564244/

Houttu N, Kalliomäki M, Grönlund MM, Niinikoski H, Nermes M, Laitinen K. Body composition in children with chronic inflammatory diseases: A systematic review. Clin Nutr. 2020 Jan 11:S0261-5614(20)30003-0.
PubMed: https://pubmed.ncbi.nlm.nih.gov/32035751

 Pellonperä O, Mokkala K, Houttu N, Vahlberg T, Koivuniemi E, Tertti K, Rönnemaa T, Laitinen K. Efficacy of fish oil and/or probiotic intervention on the incidence of gestational diabetes in an at-risk group of overweight and obese women – a randomized, placebo-controlled, double-blind clinical trial. Diabetes Care 2019; 42(6):1009-1017. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/30967436

Laitinen K, Mokkala K. Overall dietary quality relates to gut microbiota diversity and abundance. Int J Mol Sci 2019; 20: 1835. doi:10.3390/ijms20081835
PubMed: https://www.ncbi.nlm.nih.gov/pubmed/31013927

Pellonperä O, Koivuniemi E, Vahlberg T, Mokkala K, Tertti K, Rönnemaa T, Laitinen K. Body composition measurement by air displacement plethysmography in pregnancy: comparison of predicted versus measured thoragic gas volume. Nutrition 2019;60:227-229.
PubMed: https://www.ncbi.nlm.nih.gov/pubmed/30677546

Pellonperä O, Koivuniemi E, Vahlberg T, et al. Dietary quality influences body composition in overweight and obese pregnant women. Clin Nutr. 2019;38(4):1613-1619.
PubMed: https://pubmed.ncbi.nlm.nih.gov/30224302/

García-Patterson A, Balsells M, Yamamoto JM, Kellett JE, Solà I, Gich I, van der Beek EM, Hadar E, Castañeda-Gutiérrez E, Heinonen S, Hod M, Laitinen K, Olsen SF, Poston L, Rueda R, Rust P, van Lieshout L, Schelkle B, Murphy HR, Corcoy R. Usual dietary treatment of gestational diabetes mellitus assessed after control diet in randomizedcontrolled trials: subanalysis of a systematic review and meta-analysis.​ Acta Diabetol. 2018.
PubMed: https://www.ncbi.nlm.nih.gov/pubmed/30328565

Yamamoto JM, Kellett JE, Balsells M, García-Patterson A, Hadar A, Sola I, Gich I, van der Beek EM, Castañeda-Gutiérrez E, Heinonen S, Hod M, Laitinen K, Olsen SF, Poston L, Rueda R, Rust P, van Lieshout L, Schelkle B, Murphy HR, Corcoy R. Gestational diabetes mellitus and diet: A systematic review and meta-analysis of randomized controlled trials examining the impact of modified dietary interventions on maternal glucose control and neonatal birth weight. Diabetes Care 2018;41:1346-1361.
PubMed: https://www.ncbi.nlm.nih.gov/pubmed/29934478

Vähämiko S, Laiho A, Lund R, Isolauri E, Salminen S, Laitinen K. The impact of probiotic supplementation during pregnancy on DNA methylation of obesity-related genes in mothers and their children. Eur J Nutr. 2018.
PubMed: https://www.ncbi.nlm.nih.gov/pubmed/29299736

Houttu N, Mokkala K, Laitinen K. Overweight and obesity status in pregnant women are related to intestinal microbiota and serum metabolic and inflammatory profiles. Clin Nutr. 2017. pii: S0261-5614(17)31433-4.
PubMed: https://www.ncbi.nlm.nih.gov/pubmed/29338886

Mokkala K, Pussinen P, Houttu N, Koivuniemi E, Vahlberg T, Laitinen K. The impact of probiotics and n-3 long-chain polyunsaturated fatty acids on intestinal permeability in pregnancy: a randomized clinical trial. Benef Microbes 2018 Feb 27;9(2):199-208.
PubMed: https://www.ncbi.nlm.nih.gov/pubmed/29345158

Mokkala K, Houttu N, Vahlberg T, Munukka E, Rönnemaa T, Laitinen K. Gut microbiota aberrations precede diagnosis of gestational diabetes mellitus. Acta Diabetol 2017.
PubMed: https://www.ncbi.nlm.nih.gov/pubmed/28980079

Röytiö H, Mokkala K, Vahlberg T, Laitinen K. Dietary fibre and fat intake in the habitual diet of overweight, pregnant women have different effects on intestinal microbiota richness and species abundance. Brit J Nutr 2017;118:343-352.
PubMed: https://www.ncbi.nlm.nih.gov/pubmed/28901891

Mokkala K, Pellonperä O, Röytiö H, Pussinen P, Rönnemaa T, Laitinen K. Increased intestinal permeability, measured by serum zonulin, is associated with metabolic risk markers in overweight pregnant women. Metabolism. 2017 Apr;69:43-50.
PubMed: https://www.ncbi.nlm.nih.gov/pubmed/28285651

Mokkala K, Tertti K, Rönnemaa T, Vahlberg T, Laitinen K. Evaluation of serum zonulin for use as an early predictor for gestational diabetes. Nutr Diabetes. 2017 Mar 20;7(3):e253.
PubMed: https://www.ncbi.nlm.nih.gov/pubmed/28319108

Mokkala K, Röytiö H, Ekblad U, Laitinen K. Opportunities for probiotics and polyunsaturated fatty acids to improve metabolic health of overweight pregnant women. Benef Microbes. 2017 Feb 7;8(1):3-15.
PubMed: https://www.ncbi.nlm.nih.gov/pubmed/27936867

Mokkala K, Röytiö H, Ekblad U, Vähämiko S, Kaartoaho M, Laitinen K. Sikiökautinen ympäristö säätelee elintapasairauksien riskiä. Suomen Lääkärilehti 2016;71:649-654.
https://research.utu.fi/converis/portal/Publication/17861510?auxfun=&lang=fi_FI

Mokkala K, Röytiö H, Munukka E, Pietilä S, Ekblad U, Rönnemaa T, Eerola E, Laiho A, Laitinen K. Gut microbiota richness and composition and dietary intake of overweight pregnant women are related to serum zonulin concentration, a marker for intestinal permeability. J Nutr 2016 Sep;146(9):1694-700.
PubMed: https://www.ncbi.nlm.nih.gov/pubmed/27466607

Hautero U, Poussa T, Laitinen K. Simple dietary criteria to improve serum n-3 fatty acid levels of mothers and their infants one month after delivery. Public Health Nutr. 2017 Feb 20(3):534-541.
PubMed: https://www.ncbi.nlm.nih.gov/pubmed/27692015

Mokkala K, Laitinen K, Röytiö H. Bifidobacterium lactis 420 and fish oil enhance intestinal epithelial integrity in Caco-2 cells. Nutr Res. 2016 Mar;36:246-52.
PubMed: https://www.ncbi.nlm.nih.gov/pubmed/26923511

Röytiö H, Jaakkola J, Hoppu U, Laitinen K. Development and evaluation of a stand-alone index for the assessment of small children’s diet quality. Publ Health Nutr 2015;18:1941-9.
PubMed: https://www.ncbi.nlm.nih.gov/pubmed/25584442

Jaakkola J, Isolauri E, Poussa T, Laitinen K. Benefits of repeated individual dietary counselling in long-term weight control in women after delivery. Maternal Child Nutr 2015;11:1041-8.
PubMed: https://www.ncbi.nlm.nih.gov/pubmed/24521459

Vähämiko S, Isolauri E, Laitinen K. Weight status and dietary intake determine serum leptin concentrations in pregnant and lactating women and their infants. Br J Nutr. 2013;110:1098-1106
PubMed: https://www.ncbi.nlm.nih.gov/pubmed/23432806

Niinivirta K, Isolauri E, Laakso P, Linderborg K, Poussa T, Laitinen K. Dietary counseling to improve fat quality during pregnancy alters maternal fat intake and infant essential fatty acid status. J Nutr 2011;141:1281-1285.
PubMed: https://www.ncbi.nlm.nih.gov/pubmed/21593355

Gage H, Raats M, Williams P, Egan B, Jakobik V, Laitinen K, Martin-Bautista E, Schmid M, Von Rosen-Von Hoewel J, Campoy C, Decsi T, Morgan J, Koletzko B. Developmental origins of health and disease: the views of first time mothers in 5 European countries on the importance of nutritional influences in the first year of life. Am J Clin Nutr. 2011;94:2018S-2024S.
PubMed: https://www.ncbi.nlm.nih.gov/pubmed/21849599

Laitinen K, Poussa T, Isolauri E. Probiotics and dietary counselling contribute to glucose regulation during and after pregnancy: a randomised controlled trial. Brit J Nutr 2009;101:1679-1687.
PubMed: https://www.ncbi.nlm.nih.gov/pubmed/19017418

Abstracts

E. Koivuniemi, K. Laitinen. Consumption of health indicator foods in preschool-aged Finnish children. 12th Nordic Nutrition Conference (NNC2020). Virtual conference. Helsinki, Finland, 14.-16.12.2020

K. Mokkala, E. Koivuniemi, N. Houttu, K. Laitinen. Adherence to the recommended diet by pregnant women. 12th Nordic Nutrition Conference (NNC2020). Virtual conference. Helsinki, Finland, 14.-16.12.2020

K. Schorr, E. Koivuniemi, K. Laitinen. The influence of obesity on eating behaviour in pregnancy. 12th Nordic Nutrition Conference (NNC2020). Virtual conference. Helsinki, Finland, 14.-16.12.2020

K. Laitinen, E. Muhli, E. Koivuniemi, Impact of previous diagnosis of gestational diabetes on lifestyle habits in the next pregnancy. 13th European Nutrition Conference (Fens 2019). Dublin, Ireland, 15.-18.10.2019

N. Houttu, K. Mokkala, K. Laitinen. Obesity status may intervene in the relation between dietary fiber intake and gut microbiota diversity. 13th European Nutrition Conference (Fens 2019). Dublin, Ireland, 15.-18.10.2019

K. Laitinen, A. Merikivi, E. Muhli, E. Koivuniemi. Use of mobile app for health promotion in normal weight and overweight or obese pregnant women. 26th European Congress on Obesity (ECO 2019). Glasgow, Scotland, 28.4-1.5.2019

E. Koivuniemi, J. Gustafsson, I. Mäkelä, V. Koivisto, K. Laitinen. Diet quality and its association with obesity in 2 to 6 year old Finnish children. 26th European Congress on Obesity (ECO 2019). Glasgow, Scotland, 28.4-1.5.2019

E. Muhli, E. Koivuniemi, K. Laitinen. Diet quality of overweight and obese women during pregnancy in a population-based study. 26th European Congress on Obesity (ECO 2019). Glasgow, Scotland, 28.4-1.5.2019

K. Mokkala, K. Laitinen. Gut microbiota diversity and dietary quality with reference to the recommended. The 12th Finnish Gut Day, 17.01 2019

N. Houttu, K. Mokkala, K. Laitinen. Degree of obesity in pregnant women is related to metabolic and inflammatory profiles. 25th European Congress on Obesity (ECO2018). Vienna, Austria, 23.-26.5.2018.

K. Laitinen, N. Houttu, K. Mokkala. High prepregnancy BMI and low dietary intake of fibre relate to increased circulating VLDL lipids in pregnant women. 25th European Congress on Obesity (ECO2018). Vienna, Austria, 23.-26.5.2018.

N. Houttu, K. Mokkala, K. Laitinen. Gut microbiota is related to obesity status in pregnant women. Poster. The 11th Finnish Gut day. 2nd February 2018.

K. Mokkala, H. Röytiö, K. Laitinen. Diverse impacts of dietary fat quality on gut microbiota richness. Poster. The 11th Finnish Gut day. 2nd February 2018.

N. Houttu, K. Mokkala, K. Laitinen . Gut microbiota is related to obesity status in pregnant women. 11th Finnish Gut Day. Helsinki, Finland, 2.2.2018

K. Mokkala. Dietary intake of fibre and gut microbiota is related to lower levels of glycoprotein acetylation, a marker of low-grade inflammation, in pregnant overweight women. Oral presentation. 21st International Congress of Nutrition (IUNS). Buenos Aires, Argentina. October 2017.

K. Laitinen. Adherence to dietary recommendations modifies gut microbiota richness and composition during pregnancy. Poster. 21st International Congress of Nutrition (IUNS). Buenos Aires, Argentina. October 2017.

K.Mokkala, H.Röytiö, E.Munukka, S.Pietilä, U.Ekblad, T.Rönnemaa, E.Eerola, A.Laiho, K.Laitinen. Gut microbiota composition and dietary intake are related to serum zonulin, a marker of intestinal permeability, of overweight pregnant women/5. Poster and oral presentation. Beneficial microbes conference. Amsterdam, The Netherlands. October 2016.

T. Rönnemaa, K. Mokkala, H.Röytiö, E. Munukka, S. Pietilä, U. Ekblad, E. Eerola, A. Laiho, K. Laitinen: Diet composition and gut microbiota composition of overweight pregnant women at risk of gestational diabetes are related to intestinal permeability. Oral presentation. European Association for the Study of Diabetes (EASD) 2016. Munich, Germany. 14th September 2016.http://www.easdvirtualmeeting.org/users/41024

K. Mokkala, K. Laitinen, H. Röytiö: Bifidobacterium lactis 420 and fish oil enhances intestinal epithelial integrity in vitro. The 12th European Nutrition Conference FENS, Berlin, Germany, 20.10-23.10, 2015.

K. Mokkala, H. Röytiö, U Ekblad, T Rönnemaa and K. Laitinen: Diet composition of overweight pregnant women is related to serum zonulin concentration, a marker for intestinal permeability. The 12th European Nutrition Conference FENS, Berlin, Germany, 20.10-23.10, 2015.

K. Mokkala, K. Laitinen, and H. Röytiö: Bifidobacterium lactis 420 and fish oil enhances intestinal epithelial integrity in vitro. Moderated poster. The 12th European Nutrition Conference FENS. Berlin, Germany. October 2015.

K. Mokkala, H. Röytiö, U Ekblad, T Rönnemaa and K. Laitinen: Diet composition of overweight pregnant women is related to serum zonulin concentration, a marker for intestinal permeability. Moderated poster. The 12th European Nutrition Conference FENS. Berlin, Germany. October 2015.

Dissertations

Outi Pellonperä: Determinants of gestational diabetes in overweight and obese women : body composition and intervention with fish oil and probiotics, 2020

Kati Mokkala: Intestinal permeability in pregnancy: dietary and microbial determinants and metabolic consequences, 2017